Morphogenic effects of halogenated thymidine analogs onDrosophila III. 5-Iododeoxyuridine
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منابع مشابه
Morphogenic effects of halogenated thymidine analogs on Drosophila. II. Incorporation of 5 -bromodeoxyuridine into DNA.
When 5-bromodeoxyuridine is fed to Drosophila larvae, a variety of morphogenic lesions are found in the hatching adults. Experiments were undertaken to determine whether 5-bromodeoxyuridine is incorporated into Drosophila DNA under the conditions which induce developmental modifications. Radioautographic techniques were used to examine the distribution of [aH lbromodeoxyuridine in Drosophila la...
متن کاملMorphogenic effects of halogenated thymidine analogues on Drosophila. VI. Causal analysis of bromodeoxyuridine induced growth lesions.
Variations in the treatment conditions which affect the frequency of BUdR-induced morphogenic lesions in Drosophila melanogaster have been studied. By varying the concentrations of BUdR and FU, or by changing the duration of treatment, it has been demonstrated that increased incorporation of BUdR into DNA results in a concomitant increase in morphogenic lesions. A quantitative analysis of the d...
متن کاملPurification of thymidine phosphorylase from Escherichia coli and its photoinactivation in the presence of thymine, thymidine, and some halogenated analogs.
Isoelectric focusing was used as the final step in the isolation of thymidine phosphorylase which was found to have an isoelectric point of 4.1. Analytical acrylamide gel electrophoresis showed the purified enzyme preparation contained one major protein band which stained for thymidine phosphorylase activity and usually a minor, faster migrating band devoid of activity. Inactivation of thymidin...
متن کاملMay Explain Mitochondrial Side Effects of Antiviral Thymidine Analogs
4 5 Liya Wang*, Ren Sun and Staffan Eriksson 6 Department of Anatomy, Physiology and Biochemistry, Section of Veterinary Medical 7 Biochemistry, SLU, The Biomedical Centre, P.O. Box 575, SE-751 23 Uppsala, Sweden 8 9 10 * Corresponding author: Tel: 46 18 471 4119; 11 Fax: 46 18 550762 12 e-mail: [email protected] 13 14 15 Running title: Thymidine kinase 2 and antiviral thymidine analogs. 16 Copy...
متن کامل5-Halogenated thymidine analogues induce a senescence-like phenomenon in HeLa cells.
We tested various thymidine analogues for induction of a senescence-like phenomenon in HeLa cells. CldU, BrdU, and IdU similarly induced the morphology of senescent cells and typical senescence markers. Thymidine analogues other than 5-halogenated forms caused only cell death. BrdU efficiently killed the cells in cooperation with irradiation with light and a brief treatment with Hoechst 33258, ...
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ژورنال
عنوان ژورنال: Experientia
سال: 1972
ISSN: 0014-4754,1420-9071
DOI: 10.1007/bf01928722